Thank you for the questions. Tbh, I'm more familiar with the role of HSV-1 in AD. Herpesviruses in general are neurotrophic, which means they infect the nervous system. So, some studies did find that EBV and other herpesviruses may increase AD risk to some extent.

But EBV doesn't exhibit a tropism for the hippocampus, so it may not hold the same thereotical power as HSV-1.

That said, I've previously written about the convincing research on EBV and multiple sclerosis (MS), where EBV is actually a prerequisite to developing MS. So put another way, MS can't develop without a prior EBV infection.

Glymphatic system buildup and CSF stagnation are also strong contributory factors to AD - similar to chronic inflammation, oxidative stress and vascular dysfunction. I find them to explain neurodegenerative diseases in general, but not AD specifically.