Thank you for commenting too. Yes, anti-depressants, typically SSRIs, do increase serotonin levels in the brain by influencing how the brain handles existing serotonin. SSRIs stand for selective serotonin reuptake inhibitor, which block serotonin uptake by cells and increase free serotonin. This means that more serotonin remains available in the synaptic space (the space between neurons) for a longer time, enhancing its effects.