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Thank you for commenting. Gift of Fire really raised a good point - that the variants seem to evolve based on natural immunity because an XBB infection would confer XBB immunity, at least for a few months. So, either XBB stays the same and infects the person months later or evolves to evade XBB-specific immunity.

That said, there's still one concern with immune imprinting - it not only mounts outdated antibodies but may also interfere with the generation of updated antibodies. So, I think the interplay between virus evolution and immunity (from both vaccination and infection) is more complicated than it seems.

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Shin Jie Yong, MSc (Res)
Shin Jie Yong, MSc (Res)

Written by Shin Jie Yong, MSc (Res)

Named Stanford's world top 1% scientists | Medium's boost nominator | National athlete | Ghostwriter | Get my Substack: https://theinfectedneuron.substack.com/

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